The findings may help to tailor visual prognosis and interpret outcomes of trials. Both visual functions showed a high degree of intereye symmetry, particularly in early stages, indicating the fellow eye can provide a suitable control for assessing interventions to one eye.

Microperimetry represents the global macular region. Near normal foveal sensitivity was maintained when the fovea was at least 2500 μm from the advancing edge of AF.īCVA is a marker of central degeneration and can provide valuable information about the position of the remaining retina as well as a measure of the impact on daily living. Intereye symmetry was more consistent for microperimetry sensitivity ( r = 0.95, P < 0.001) than BCVA ( r = 0.42, P = 0.0006). Zonal analysis showed faster decline nasal to the fovea. Macular sensitivity showed a similar decline in right and left eyes, with half-lives of 13.6 years. Survival analysis showed an indistinguishable pattern between eyes (median survival 39 years). Microperimetry coefficient of repeatability was 1.45 dB. Kaplan-Meier survival plots of eyes retaining 20/20 BCVA were created. Microperimetry was repeated in 21 eyes and analyzed with Bland-Altman. We investigated visual function in CHM by correlating best-corrected visual acuity (BCVA), microperimetry and multimodal imaging.įifty-six consecutive CHM patients attending Oxford Eye Hospital were examined with BCVA, 10–2 microperimetry, optical coherence tomography, and fundus autofluorescence (AF). The latter marks an acute decline in quality of life but visual prognostication remains challenging.

Centripetal retinal degeneration in choroideremia (CHM) leads to early visual field restriction and late central vision loss.

Sigmaplot 11 do not test bonferroni